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Short Term and Long Term Side Effects of Magic Mushrooms

Magic Mushrooms Side Effects Brain

Magic mushrooms side effects can effect your brain and body in the long and short term. This can happen even from taking only a single dose.

Magic mushrooms are popular with many different names to include Shrooms, Psychedelic mushrooms and Psilocybin mushrooms. They are also commonly thought of as just another form of drug.

Actually, they have some amazing health benefits to include treating depression, anxiety, PTSD and curing addiction in only one dose.  Here is an article we wrote to learn more about their health benefits:

mushroom for depression anxiety ptsd

Psilocybin mushrooms are technically considered a controlled substance in many countries. In the USA the federal government has them classified as number 1 drug meaning it doesn’t have any medicinal purposes. Besides, it has high potential for abuse. We know this is 100% inaccurate based on all the clinical studies you can read I linked to above.

If you are worried about a drug test most standard drug tests don’t even test for it. And if they do it normally only stays in your system for up to 24 hours. In some cases this could last to 3 days for people regularly using or abusing it according to Columbia University.

There are some specialized drug testing companies like Quest Diagnostics and NMS Labs that offer specialized test for psilocybin.

Now let’s see what the side effects are on our brain and body with short and long term use…

Side Effects of Magic Mushrooms on Health

Most side effect from taking magic mushrooms that have been reported are very spiritual experiences and are positive in nature.

They consist of people being able to see the true liquid state of the world and of all things around them.  This can be scary to some but the idea is to give your self into it and let your self experience it and to trust it.

Most people that try to fight the experience or control it end up resulting in whats referred to as a ‘bad trip’.  During these ‘bad trips’ is when most people will report negative side effects.

Short-Term Effects of Magic Mushrooms

The short term effects can be different for everyone but we will discuss some common ones that most people will experience if you take between 1 to 7 grams of dried psilocybe cubensis.

The important thing to notice with these side effects is they are short term while you are in your trip and most of them result in a good outcome when you come down after 6 hours or less later.

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Most Likely to occur [7]:

  1. Heightened senses
  2. Inability to determine what’s real
  3. Feeling connected with the environment
  4. Increased heart rate
  5. Temporarily hallucinating
  6. Euphoria
  7. Peacefulness
  8. Spiritual awakening
  9. Derealization:  Feeling the your surrounds are not real
  10. Depersonalization: Being in a dream like state where you are disengaged from your surroundings
  11. Alterations to sense:  Seeing sound and hearing colors
  12. Disorientation
  13. Muscle relaxation
  14. Trouble focusing
  15. Dilated pupils
  16. Distorted thinking

Some people can experience nausea too when taking the mushrooms but you should try not to throw it up as you will waste the experience (If you have taken more than the recommended dosage of 7 grams them you should allow your self to throw up).

magic mushroom experience

Short Term Bad Effects of Magic Mushrooms

Less likely to occur but may if you have a bad trip or take more than 7 grams (not recommended) [7]:

  1. Restlessness
  2. Thinking problems
  3. Tension
  4. Anxiety
  5. Paranoia
  6. Depression
  7. Panic
  8. Cramps
  9. Vomiting
  10. Diarrhea
  11. Dry mouth
  12. Sweating
  13. Chills
  14. Numbness
  15. Quickly changing emotions
  16. Dizziness
  17. Drowsiness
  18. Muscle weakness
  19. Lack of coordination
  20. Unusual body sensations
  21. Nausea
  22. Paranoia
  23. Confusion
  24. Frightening hallucinations
  25. Yawning
  26. Temporary loss of muscle control and muscle strength (only if you take more than 7 grams which is not recommended anyway) [5].

In general I think we could agree that these symptoms are nothing too horrible.  I mean no where in there did I say pooping blood, heart attach or death…just saying because almost every prescription drug you take has much more horrible side effects then these.

Not to mention that other than the hallucinations almost every prescription drug would have many of these same symptoms.

**Beware that you may or may not experience many of these symptoms as it effects everyone differently.**

spiritual experience

Long-Term Effects of Magic Mushrooms

When it comes to the long term effects of shrooms there are not any credible studies out there to prove any real negative side effects.

Most long term effect consist of positive things such as:

  1. Permanently quitting addictions such as smoking or opioid addictions [3].
  2. Increase in sense of well-being and life satisfaction [5].
  3. New sense of love and connection with every living thing around them [4].
  4. Heightened mental state and improved ways of thinking [5].
  5. Being able to think back on their experience and regain many of the positive effects as if they took another dose [5].
  6. Improved symptoms of depression, anxiety and post traumatic stress disorder (PTSD) years after a single dose [6].

Other Side Effects

Here are some other side effects that get mentioned quite a bit with an explanation to make sense of it:

  1. Studies have shown that they can permanently alter your brain however that could be a good thing [1].
  2. Some websites report magic mushrooms being linked to inducing psychosis however recent studies done in controlled environments show they are not associated [2].
  3. Dr. Weinstein (Chief medical officer of American Addiction Centers) reports that psychosis can be brought on by psilocybin which puts individuals with a family history of schizophrenia or other pyschotic disorders are risk of experiencing a psychotic episode.

I would like to take the time to clear up the Hallucinogen Persisting Perception Disorder (HPPD) myth.  Many sites report that psilocybin can cause HPPD but they are all hypothetical because the people that have experienced HPPD abused other drugs along with psicloybin.

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Bill Richards who is a psychologist at Johns Hopkins has led hundreds of psychedelic-assisted therapy sessions with psilocybin since the 1970s.  He states the following:

“I personally have encountered no reports of HPPD,” Richards added. “Of course this is with pure psilocybin (synthesized) in reasonable dosage without any other substances in medically screened volunteers.”

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magic mushrooms side effects brain body

Prescription Drugs vs Magic Mushrooms

Through many studies it has been shown that magic mushrooms are a very powerful substance that can have a major impact on depression, anxiety, PTSD, overall quality of life and provide such a life change experience that you will have a whole new outlook on life in general.  You will have a new sense of love for yourself and everyone/everything around you.

In another sense it makes you a better leader as well because it eliminates your fear of dying while making you a more caring and nice person.  These are very good leadership qualities to have.

When it comes to prescription drugs, I think Joe Rogan says it best in a podcast he had with Paul Stamets:

Joe Rogan talks about how magic mushrooms give you the potential to heal while all the other prescription drugs numb you out and are basically escape drugs.  That’s why in only one dose so many people have reported being cured from their mental health illness related issues.  It’s because it allows them to heal instead of just escaping.

The problem with escape drugs is eventually you have to come back to reality and face the pain again.  With magic mushrooms you are forced to take a hard look at reality in a way you have never seen it before and that how you begin to be healed.  It eliminates the need to escape.

Side effects of prescription drugs compared to magic mushrooms:

Antidepressant Prescription Drugs Side Effects [8]

  1. Increased appetite
  2. Weight gain
  3. Fatigue/drowsiness
  4. Dry mouth
  5. Blurred vision
  6. Insomnia
  7. Dizziness
  8. Indigestion/stomach aches
  9. Diarrhea/constipation
  10. Addictive

Magic mushroom Side Effects

You can look above to see all the magic mushroom side effects but when comparing them to common prescription drugs to treat depression here is how they compare:

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  1. Don’t cause weight gain
  2. Don’t cause insomnia
  3. Doesn’t cause dizziness
  4. They are NOT addictive and therefore does NOT have a potential for substance abuse

One cool thing is they are actually anti-addictive by nature.  This means you won’t feel the need to take them more than one time.  Actually, the next day after you consume the mushrooms if you look at them you will thinking to yourself, “no way man…I am not touching those things again for a long, long time”.  This is because of how powerful they are.

The main thing to keep in mind is there is no reason to do more than 7 grams and always make sure you are in a safe environment prior to consuming them.

Some people have reported to have bad ‘trips’ and this is normally because they did not put themselves into a safe place prior to consuming the mushrooms.  Another reason is because they try to control the experience instead of giving themselves into it.

They key is free your mind of everything prior to eating them and let the mushrooms take you where you need to go.  DO NOT try to stop the mushrooms from taking your somewhere (in your mind) or try to control it in any way…Remember that the mushrooms are here to help and you need to trust them.

Wrapping Up

Magic mushrooms have some really amazing health benefits to include being a treatment for depression, anxiety, PTSD and even curing addiction in only one dose.

While there are some side effects of magic mushrooms they really aren’t ‘side’ effects as much as they are the ‘actual’ effects of the mushroom.  What I mean is the whole purpose of taking these mushrooms is to alter your reality and reveal to you a whole new world that you weren’t aware of before.

The good news is these mushroom are NOT addictive and they really don’t have any known negative side effects on our brain or bodies and the only reported long term side effects are that the positive experiences lives with the person for the rest of their lives.

From here I recommend you check out our articles on the different types of mushrooms and the correct dosage amount to take as well as the importance of having the correct setting so you don’t experience any negative side effects that you aren’t ready for:

magic mushroom dosage



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The following presentations contain images/videos that were used under a Creative Commons License. Click the links below to see the full list of images/videos and attributions:

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Legal Disclaimer:

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Psilocybin remains illegal under federal law in the United States.  We do not advocate for, endorse, or intend for this report to be used to violate federal law.



Curative Mushrooms has to post the standard FDA Disclaimer…The statements made regarding medicinal mushrooms have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. Curative Mushrooms is not making claims intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other possible complications before consuming the medicinal mushrooms. The Federal Food, Drug and Cosmetic Act requires this notice.


This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Curative Mushrooms nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.


Always looking for ways to improve the health of myself and my family led me to the discovery of medicinal mushrooms and the numerous health benefits they have on the body. My mission is to spread this knowledge and help as many people as possible.

This Post Has 32 Comments

    1. Prahaps suggest people just take small amounts of mushroom at first. So as not to scare themselves half to death.

  1. I have read so much I am now overwhelmed I don’t know what the deal or wants not, I will have to think on it for a while. Thanks for all the information.

  2. I am a disabled combat vet. I have many of the mental illnesses mentioned. PTSD, ANXIETY, DEPRESSION. Been on opioids for years.
    I’m hoping and praying that this can help me.
    I’ll let you know after I’ve tried it.

  3. There’s a ton of information here I am glad to push through ! Thanks I’ve been looking for this for quite a while!

  4. I think my order went through. It went back a screen an when I filled it out again it said it was a duplicate order. Please check.

  5. Are y’all fucking nuts/stupid????? When I lived in Gainesville FL. We ate one to seven pounds of what you call “shrooms “ every day… not one to seven pitiful “GRAMS”… the only problem/side effects, was that it always wore off/came down, and had to go out the next day and do it over

  6. looking forward to getting this. I am one of rhe depressed, anxious, ptsd group of people. I take a handful of pills for these symptoms. I’ve have heard stories about the effects of magic mushrooms. I am worried about relaxing into the trip. if there is a guideline into this, I’d like to see it.

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